Hereditary and Germline Panels
BRCA1/BRCA2, BRCA1/BRCA2/PALB2, Lynch syndrome, hereditary cancer, and CFTR options.
Precision Oncology and Inherited Disease
OncoDx Molecular Oncology
Targeted next-generation sequencing panels for cancer-related and inherited-disease variant analysis.
The current OncoDx menu includes focused BRCA, Lynch syndrome, myeloid, colorectal, lung, pan-cancer, hereditary cancer, and CFTR panels. Specimen types vary by assay and include FFPE, fresh-frozen material, whole blood, cfDNA, cell lines, and genomic DNA.
Panel selection, specimen suitability, intended use, and reportable scope should be confirmed with B&B Bio before testing.
Panel Menu
Focused and Broad NGS Options
Choose focused gene panels or broader disease-oriented coverage based on the molecular question, specimen, and required analysis.
Solid-Tumor Panels
Colorectal, lung, and pan-cancer NGS panels with focused hotspot and exon-level coverage as listed for each assay.
Myeloid Panel
A 23-gene myeloid panel with comprehensive and exon-level hotspot coverage and full TP53 coverage as described on the current page.
Current Panel Catalog
Oncology and Inherited Disease NGS Panels
Panel descriptions, gene lists, specimens, and sensitivity values below are reorganized from the current B&B Bio OncoDx page.
Hereditary / Oncology
BRCA1/BRCA2 Panel
The current page states that the assay sequences all exons, including intron-exon junctions, for both BRCA1 and BRCA2 using NGS.
Genes: BRCA1, BRCA2
Hereditary / Oncology
BRCA1, BRCA2, PALB2 NGS Panel
Covers the entire coding sequence of BRCA1 and BRCA2 and all coding exons plus the 5-prime and 3-prime UTR regions of PALB2.
Genes: BRCA1, BRCA2, PALB2
Inherited Disease
CFTR NGS Panel
A comprehensive CFTR panel covering all exons, 5-prime and 3-prime UTRs, selected intronic regions, and ACMG-recommended mutations as described on the current page.
Genes: CFTR
Hereditary / Oncology
Lynch Syndrome NGS Panel
Identifies variants in DNA mismatch-repair genes with comprehensive and exon-level hotspot coverage of four clinically relevant genes.
Genes: MLH1, MSH2, MSH6, PMS2
Hematologic Oncology
Myeloid NGS Panel
The current page describes comprehensive and exon-level hotspot coverage of 23 myeloid disease-related genes, including full TP53 coverage.
View genes
ASXL1, CALR, CEBPA, CSF3R, DNMT3A, EZH2, FLT3, HRAS, IDH1, IDH2, JAK2, JAK3, KDM6A, KIT, MPL, NPM1, RUNX1, SETBP1, SF3B1, SRSF2, TET2, TP53, U2AF1
Solid Tumor
Colorectal Cancer NGS Panel
Offers comprehensive and exon-level hotspot coverage of 16 colorectal-cancer genes, with full TP53 coding-region coverage and ERBB2 CNV detection described on the current page.
View genes
AKT1, APC, BRAF, ERBB2, ERBB4, KIT, KRAS, NOTCH1, NRAS, PDGFRA, PIK3CA, POLE, PTEN, SMAD4, STK11, TP53
Solid Tumor
Lung Cancer NGS Panel
The current page describes comprehensive and exon-level hotspot coverage of 17 genes relevant to small-cell and non-small-cell lung cancer.
View genes
AKT1, ALK, ARAF, BRAF, EGFR, ERBB2, ERBB4, FGFR1, FGFR2, FGFR3, KRAS, MAP2K1, MET, NRAS, PIK3CA, PTEN, TP53
Broad Oncology
Pan-Cancer NGS Panel
A 57-gene pan-cancer panel with comprehensive and hotspot coverage, sample-identification markers, and full TP53 exon coverage as described on the current page.
View genes
ABL1, AKT1, ALK, APC, ATM, BRAF, CDH1, CDKN2A, CSF1R, CTNNB1, DDR2, DNMT3A, EGFR, ERBB2, ERBB4, EZH2, FBXW7, FGFR1, FGFR2, FGFR3, FLT3, FOXL2, GNA11, GNAQ, GNAS, HNF1A, HRAS, IDH1, IDH2, JAK2, JAK3, KDR, KIT, KRAS, MAP2K1, MET, MLH1, MPL, MSH6, NOTCH1, NPM1, NRAS, PDGFRA, PIK3CA, PTEN, PTPN11, RB1, RET, SMAD4, SMARCB1, SMO, SRC, STK11, TP53, TSC1, TSC2, VHL
Assay details shown here reflect the current live page. Confirm current test availability, specimen requirements, validated performance, and reporting scope before ordering.
Hereditary Cancer
Expanded Hereditary Cancer Coverage
The current hereditary cancer panel is described as covering 113 genes associated with hereditary breast, colon, ovarian, gastric, and other cancer predispositions.
Hereditary Cancer Panel
The panel is described as covering mutations in 113 genes frequently associated with hereditary cancer predisposition and targeting 125 associated single-nucleotide variants linked with cancer risk.
View full 113-gene list
ACD, AIP, AKT1, APC, ATM, BAP1, BARD1, BLM, BMPR1A, BRCA1, BRCA2, BRIP1, CASR, CDC73, CDH1, CDK4, CDKN1B, CDKN2A, CEBPA, CHEK2, CTRC, DDB2, DICER1, DIS3L2, EPCAM, ERCC1, ERCC2, ERCC3, ERCC4, ERCC5, FAM175A, FANCA, FANCB, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCL, FANCM, FH, FLCN, GALNT12, GATA2, GPC3, GREM1, HOXB13, KIF1B, KIT, LZTR1, MAX, MEN1, MET, MITF, MLH1, MRE11, MSH2, MSH3, MSH6, MUTYH, NBN, NF1, NF2, NSD1, NTHL1, PALB2, PDGFRA, PHOX2B, PIK3CA, PMS2, POLD1, POLE, POT1, PRKAR1A, PTCH1, PTEN, RAD50, RAD51, RAD51B, RAD51C, RAD51D, RB1, RECQL4, RET, RHBDF2, RINT1, RUNX1, SDHA, SDHAF2, SDHB, SDHC, SDHD, SLX4, SMAD4, SMARCA4, SMARCB1, SMARCE1, SPINK1, SPRED1, STK11, SUFU, TERF2IP, TERT, TMEM127, TP53, TSC1, TSC2, VHL, WT1, XPA, XPC, XRCC2
Breast Cancer
ATM, BARD1, BRCA1, BRCA2, CDH1, CHEK2, NBN, NF1, PALB2, PTEN, STK11, TP53
Colon Cancer
APC, AXIN2, BMPR1A, CHEK2, EPCAM, GREM1, MLH1, MSH2, MSH6, PMS2, MSH3, MUTYH, NTLH1, POLD1, POLE, PTEN, SMAD4, STK11, TP53
Ovarian Cancer
ATM, BARD1, BRCA1, BRCA2, CDH1, CHEK2, NBN, NF1, PALB2, PTEN, STK11, TP53
Gastric Cancer
CDH1
Other Cancers
MEN1, NF2, RB1, RET, SDHAF2, SDHB, SDHC, SDHD, TSC1/2, VHL, TP53, WT1
Choose the Right Panel for Your Project
Contact B&B Bio to review panel selection, specimen requirements, sequencing scope, and reporting needs before submission.
Panel descriptions and performance statements should be confirmed against the laboratory's current validated documentation before clinical use or ordering.